Histochemistry and translational medicine

Histochemistry and translational medicine.

T his issue of the Journal is mainly devoted to a specific, crucial topic in the field of histochemical research: how in situ technologies can be exploited to study tissue samples from patients with specific diseases. The final goal is on one hand a more accurate diagnosis; on the other, the identification of specific features that can: i) be followed and compared at different time points ii) p...

Optogenetics and translational medicine.

Optogenetic tools enable light-mediated control of cellular excitability and signaling in vivo. By manipulating biological processes, scientists can determine the roles played by these processes in intact biological systems, such as the brain. Such cellular-level control has greatly affected basic science. Here, we discuss how optogenetic tools might be translated into clinical impact through i...

Translational Medicine and Fido

Biotechnology and Translational Medicine

The process of translating a basic scientific discovery into a novel therapeutic that improves public health is immensely gratifying. A particularly exciting time in the translation process is the early clinical testing to assess—for the first time—whether a novel molecule is efficacious in humans. This “proof-of-concept” (POC) stage of translation has a high risk of failure and must be careful...

Translational Medicine